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KMID : 0362420140520040298
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Journal of Korean Academy of Prosthodontics
2014 Volume.52 No. 4 p.298 ~ p.304
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Osseointegration of the titanium implant coated with rhTGF-β2/PLGA particles by electrospray: a preliminary microCT analyzing rabbit study
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Lee Woo-Sung
Kim Seong-Kyun
Heo Seong-Joo
Koak Jai-Young
Lee Joo-Hee
Park Ji-Man
Park Yoon-Kyung
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Abstract
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PURPOSE. This preliminary rabbit study was conducted to evaluate the effect of recombinant human transforming growth factor-β2 (rhTGF-β2)/poly lactic-co-glycolic acid (PLGA) coating on osseointegration of the titanium (Ti) implant.
MATERIALS AND METHODS. Eight Ti implants were anodized with 300 voltages for three minutes. Four of those were coated with rhTGF-β2/PLGA by an electrospray method as the experimental group. The implants were placed into tibiae of four New Zealand rabbits, two implants per a tibia, one implant per each group. After 3 and 6 weeks, every two rabbits were sacrificed and micro-computed tomography (microCT) was taken for histomorphometric analysis.
RESULTS. In scanning electron microscope (SEM) image, the surface of rhTGF-β2/PLGA coated Ti implant showed well distributed particles. Although statistically insignificant, microCT analysis showed that experimental group has higher bone volume / total volume (BV/TV) and trabecular thickness (Tb.Th) values relatively. Cross sectional view also showed more newly formed bone in the experimental group.
CONCLUSION. In the limitation of this study, rhTGF-β2/PLGA particles coating on the Ti implant show the possibility of more favorable quantity of newly formed bone after implant installation.
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KEYWORD
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TGF-beta2, PLGA, Titanium, Implant, Osseointegration
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